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Desmopressin Advice

There are 2 formulations of this drug.

Desmotabs

       Classical tablets each containing 0.2 mg of drug. One or two tablets may be needed

Desmomelts

      A newer form of the drug which dissolves on the tongue. They contain either 120 mcg or 240 mcg of drug.

How does it work?

Desmopressin is a man-made version of the hormone Argenine Vasopresin (AVP). This hormone is secreted from the pituitary gland in the middle of the brain. It regulates the amount of water re-absorbed by the kidney. More hormone means more water re-absorption and therefore less urine is produced.

Why do we give it?

By decreasing the amount of urine produced the likelihood of having a 'full bladder' is reduced. It does not cure the problem, but helps manage it.

When should we give it?

On nights away from home. Before this use it for a few nights at home to ensure it is effective.

What time do we give it?

Just before bed. If there is wetting early in the night, then try giving the desmopressin 1hr before bed.

How much do we give?

Start with the lower dose (Tablets 200 mcg / Melt 120 mcg). This can be increased to the higher dose (Tablets 400 mcg / Melt 240 mcg) if the lower dose does not work.

How much should children you drink if they are taking desmotabs?

We recommend you only drink water and only drink to thirst. Children do not normally need to drink after they have gone to bed. Drinks should be limited an hour before bedtime. Older adolescents should not take desmopressin if they have had alcohol.

What are the side effects?

If your body cannot remove excess fluid you can become water overloaded. This can result in headaches and convulsions (seizures or fits). This is extremely rare, however it is for this reason we make the recommendation about how much you should drink. Stomach pain, headache, nausea, and vomiting have also been reported.